Infertility affects millions of couples worldwide. While many cases are attributed to conditions like PCOS, low sperm count, or blocked fallopian tubes, around 15-30% of infertility cases remain "unexplained." In these situations, couples are unable to conceive despite normal test results and good reproductive health.
Unexplained infertility is a medical challenge that demands in-depth evaluation and personalized treatment. At Ashakiran Hospital in Pune, the team takes a systematic, high-tech approach to diagnosing the root causes and creating targeted fertility plans that lead to success.
Unexplained infertility is diagnosed when all the following conditions are met:
Regular ovulation is confirmed
Fallopian tubes are open
Sperm analysis is within normal limits
Uterus appears normal on ultrasound
Despite these findings, pregnancy does not occur after 12 months of trying (or 6 months for women over 35).
The difficulty lies in the fact that standard diagnostic tools may not detect subtle abnormalities. Hidden conditions such as:
Early-stage endometriosis
Minor uterine defects
Egg-sperm incompatibility
Poor embryo quality
Immunological or genetic factors
...may be responsible, even if they aren’t visible on routine tests. That’s why Ashakiran Hospital emphasizes advanced fertility diagnostics to uncover the deeper causes.
AMH levels give a snapshot of a woman’s ovarian reserve. A very low or high AMH can suggest problems with egg quantity or conditions like PCOS—both often missed in routine infertility workups.
➡ Explore more: Ovulation Disorders Treatment
Ashakiran goes beyond sperm count. They evaluate:
Sperm morphology
Motility
DNA Fragmentation Index (DFI)
This comprehensive analysis helps identify subtle male-factor infertility, which is often overlooked in “unexplained” cases.
A camera-assisted evaluation of the uterine cavity reveals polyps, fibroids, or uterine septa that may interfere with embryo implantation.
Minimally invasive, this procedure allows direct visualization of pelvic organs. It’s crucial for detecting:
Mild endometriosis
Pelvic adhesions
Tubal disease undetected in HSG
Ashakiran conducts thyroid, prolactin, insulin, and vitamin D tests along with karyotyping to uncover hidden metabolic or chromosomal contributors.
After thorough diagnosis, a personalized treatment plan is created, depending on age, health, duration of infertility, and test results.
Weight management, stress reduction, and a PCOS-friendly diet are first steps. These improve ovulation, hormonal balance, and overall reproductive health.
➡ Related service: Lifestyle Counselling
For women with regular periods but poor egg quality or unexplained infertility, Letrozole or Clomiphene Citrate are prescribed to enhance ovulation.
In cases with mild male factor or unknown causes, IUI offers an affordable, minimally invasive option. It increases sperm-egg interaction by placing processed sperm directly into the uterus.
For couples above 35, or those with failed IUI cycles, IVF offers control over fertilization and embryo selection. IVF is highly successful in unexplained infertility, especially when enhanced by embryo monitoring.
➡ Learn more: IVF and ICSI Services
These techniques assist fertilization and implantation in IVF—especially useful in cases with sperm binding issues or multiple failed embryo transfers.
Dr. Ashish Kale is one of India’s leading infertility specialists and the Director of Ashakiran Hospital. With over 20 years of experience in reproductive medicine, gynecological endoscopy, and IVF, he has been instrumental in revolutionizing fertility care in Pune.
His expertise combines technical precision with compassionate patient care, earning him trust from couples across the country. Dr. Kale believes in empowering patients through knowledge and offering hope even in the most complex infertility cases.
Expert Team: Reproductive endocrinologists, embryologists, and counselors
Advanced Infrastructure: Modern IVF lab, 3D laparoscopy, hormone analysis
Integrated Approach: Combines clinical, emotional, and lifestyle care
Transparent Treatment Plans: No hidden costs or rushed procedures
Neha (31) & Aman (34) had unexplained infertility for 2 years. After a hysteroscopy revealed a small fibroid, surgical correction followed by IUI led to a successful pregnancy within three cycles.
Pooja (35) had three failed IUIs elsewhere. At Ashakiran, advanced semen analysis revealed DNA fragmentation. After a tailored IVF+ICSI cycle, she conceived twins.
Q1. What makes infertility “unexplained”?
When all basic tests are normal but pregnancy doesn’t happen, the case is termed unexplained.
Q2. Can AMH affect fertility even if periods are regular?
Yes—low AMH can suggest poor ovarian reserve despite regular cycles.
Q3. Is laparoscopy mandatory?
It’s optional but recommended in long-standing unexplained cases or after failed IUI/IVF.
Q4. How many IUIs should I try before IVF?
Most couples try 3–4 IUI cycles before considering IVF.
Q5. Can unexplained infertility be treated naturally?
Sometimes. Lifestyle changes, supplements, and timed intercourse can help restore fertility.
Unexplained infertility may feel like a dead end—but with the right tools, expertise, and personalized care, it can become a solvable puzzle. Ashakiran Hospital in Pune, led by the highly regarded Dr. Ashish Kale, is dedicated to turning unanswered questions into successful pregnancies through innovation, compassion, and clarity.
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